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The Protein Structure Initiative (PSI) is an ongoing
effort begun in 2000 to accelerate discovery in structural genomics and
contribute to understanding biological function. Funded by the U.S. National
Institute of General Medical Sciences (NIGMS), its aim is to reduce the cost
and time required to determine three-dimensional protein structures and to
develop techniques for solving challenging problems in structural biology,
including membrane proteins. Over a dozen research centers have been supported
by the PSI for work in building and maintaining high-throughput structural
genomics pipelines, developing computational protein structure prediction
methods, organizing and disseminating information generated by the PSI, and
applying high-throughput structure determination to study a broad range of
important biological and biomedical problems.
The project has been organized into three separate
phases. The first phase of the Protein Structure Initiative (PSI-1) spanned
from 2000 to 2005, and was dedicated to demonstrating the feasibility of
high-throughput structure determination, solving unique protein structures, and
preparing for a subsequent production phase.The second phase, PSI-2,
focused on implementing the high-throughput structure determination methods
developed in PSI-1, as well as homology modeling and addressing bottlenecks
like modeling membrane proteins. The third phase, PSI:Biology, began in 2010
and consists of networks of investigators applying high-throughput structure
determination to study a broad range of biological and biomedical problems.
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